Forensic Toxicology Instrumentation - LCMSMS
This 16-hour course presents a comprehensive overview of the theory and practical application of liquid chromatography tandem mass spectrometry (LC/MS/MS) instrumentation in forensic toxicology. Topics to be presented include basic LC theory and operation, basic mass spectrometer theory and operation as it pertains to LC, instrumental set-up and configuration, the use of LC/MS and LC/MS/MS in forensic toxicology, and qualitative and quantitative analyses. In addition, method development, validation, and proficiency testing will be discussed. Specific applications topics include analysis of common drugs of abuse, general unknown screens and specialized analyte screens (e.g., benzodiazepines, thermally labile drugs, quaternary ammonium compounds, HGH, insulin) and quantitations. Trace evidence analysts may be interested in general LC/MS/MS principles and selected discussions about applications of LC/MS/MS to explosives residue analysis.