Controlled Substance Utilization Review and Evaluation System

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AB 149 – New Requirements for Rx Forms

Beginning January 1, 2021, the only California controlled substances prescription forms that will remain valid and acceptable by pharmacies will be those possessing a 12 character serial number and corresponding barcode compliant with the requirements introduced in Assembly Bill 149. For more information about these requirements, please review the following bulletin, which has been jointly released by the California Department of Justice and the California Department of Consumer Affairs: AB 149 – New Requirements for Rx Forms. If you need to acquire new forms, please consult the Approved List of Security Prescription Printers.

CURES Access and Use Regulations

Final regulations pertaining to the Controlled Substance Utilization Review and Evaluation System (CURES) have been posted. The promulgated regulations contain policies and procedures governing the access and use of CURES. Relevant information concerning these regulations, including the Final Statement of Reasons and related documents, may be found on the following webpage of the Office of Attorney General’s website:

Controlled Substance Utilization Review and Evaluation System

California’s Prescription Drug Monitoring Program

CURES 2.0 (Controlled Substance Utilization Review and Evaluation System) is a database of Schedule II, III and IV controlled substance prescriptions dispensed in California serving the public health, regulatory oversight agencies, and law enforcement. CURES 2.0 is committed to the reduction of prescription drug abuse and diversion without affecting legitimate medical practice or patient care.

The operation of CURES complies with all applicable federal and state privacy and security laws and regulations. The controlled substances dispensation history of an individual that is received by a practitioner or pharmacist from CURES is subject to the Confidentiality of Medical Information Act and the Health Insurance Portability and Accountability Act of 1996 (HIPAA), including the HIPAA regulations in 45 Code of Federal Regulations parts 160 and 164.

Access to CURES 2.0 is strictly limited. Licensed prescribers and licensed pharmacists may access information in CURES only for patients under their care. Regulatory agency officials and law enforcement officials may access information in CURES only to assist the efforts of their agencies to control the diversion and resultant abuse of controlled substances.

CURES Registration Requirements

California law (Health and Safety Code Section 11165.1) requires all California licensed prescribers authorized to prescribe scheduled drugs to register for access to CURES 2.0 by July 1, 2016 or upon issuance of a Drug Enforcement Administration Controlled Substance Registration Certificate, whichever occurs later. California licensed pharmacists must register for access to CURES 2.0 by July 1, 2016, or upon issuance of a Board of Pharmacy Pharmacist License, whichever occurs later.

Prescriber and dispenser registration to access CURES 2.0 is simple and fully automated. Prescribers and dispensers can register to access CURES by clicking here.

CURES Mandatory Consultation

Mandatory CURES consultation, under Section 11165.4 of the Health and Safety Code, became effective on October 2, 2018. Please refer to the CURES Mandatory Use reference sheet, CURES Advisory Memo and the Medical Board of California’s FAQs for additional information regarding the CURES consultation requirement.

Submission of Controlled Substance Data

California Health & Safety Code Section 11165(d) requires dispensing pharmacies, clinics, or other dispensers of Schedule II through IV controlled substances to provide specified dispensing information to the Department of Justice on a weekly basis in a format approved and accepted by the DOJ. Currently, the ASAP 2009 Version 4.1 format is accepted.

Direct Dispense Reporting Application

The DOJ, in coordination with Atlantic Associates, Inc. (AAI), allows direct dispense prescribers and entities, including pharmacies filling less than 25 prescriptions per month, to electronically report dispensing data to the DOJ. The direct dispense application can be accessed on the Direct Dispense website. Also available at this website are instructions on how to apply for an account and submit dispense data. Please note that the DOJ no longer accepts paper direct dispense reports.

To access the secured direct dispense site, dispensers must first complete the application at Once an application has been submitted, an email confirmation from AAI will provide approved users with a username and temporary password. If an email confirmation is not received within 48 hours of submitting the application, please contact AAI at or (800) 539-3370.

For additional information concerning controlled substance prescription data reporting, please contact AAI at or (800) 539-3370.

Research Requests

In accordance with California Health & Safety Code section 11165(c)(2)(A) CA DOJ may provide CURES data to public or private entities, as approved by the CA DOJ, for educational, peer review, statistical, or research purposes, provided that the patient information, including any information that may identify the patient, is not compromised.

To request CURES data for any of the above listed purposes, or for additional information about the data request process, you can go to the Research Center “Data Request Process” website at


Obtain Security Prescription Forms

California law requires prescribers of any Schedule II through V controlled substance to obtain and use tamper-resistant prescription forms ordered only from state-approved security printers. To order tamper-resistant prescription forms, please refer to the Approved List of Security Prescription Printers for vendors authorized by the DOJ and their contact information.

Report Lost or Stolen Prescription Forms

Reports of lost or stolen prescription forms or pads must be reported to local law enforcement and the PDMP. Users registered with CURES can electronically report their lost or stolen prescription forms or pads online when logged into their CURES account. A law enforcement agency report number is required when submitting a report of lost or stolen prescription forms to the PDMP.

For questions concerning how to report lost or stolen prescription pads or forms, please contact the Security Prescription Printer Program at